This tab has 2 functions:
The top setting controls the start up mode of the analysis software. If the option is unticked then when you start analysis you are given the option of the start up mode. If this box is ticked then you can skip this option and force the software to start in a particular mode.
The other settings control how variables are activated and which variables are calculated when a run is loaded. For more information about these options please check this link: Variable calculation